Long-Term Health Risks Linked to Severe COVID-19 Illness

Wed 19th Mar, 2025

Individuals who required hospitalization due to severe COVID-19 illness face a significantly elevated risk of developing serious health complications even 30 months after their recovery. A comprehensive study conducted in France, which involved nearly 64,000 COVID-19 patients and a control group of 320,000 individuals, highlights these alarming findings.

The research, published in the journal Infectious Diseases, indicates that former COVID-19 patients have a 22% higher likelihood of being readmitted to the hospital due to acute cardiovascular conditions. Furthermore, the risk of mental health issues is 41% greater in this group, while hospitalizations for neurological disorders are 50% more frequent compared to the control group. Respiratory diseases also lead to over twice the number of hospital admissions among former COVID-19 patients than their counterparts.

The study tracked individuals who were hospitalized between January 1 and August 30, 2020, comparing their health outcomes with those of a matched control group who did not require hospitalization for COVID-19 during the same period. The cohort of COVID-19 patients averaged 65 years of age and was monitored for up to 30 months post-discharge.

The findings revealed a total mortality rate of 5,218 deaths per 100,000 person-years among the COVID-19 cohort, compared to 4,013 deaths per 100,000 person-years in the control group. This represents a 30% increase in mortality risk for individuals recovering from severe COVID-19.

While the initial six months post-recovery showed some improvement in health outcomes, significant differences between the two groups persisted for up to 30 months. The study noted that neurological and respiratory issues, along with chronic kidney failure and diabetes, maintained a statistically significant increased risk throughout this period.

Additionally, after 30 months, the incidence of myocarditis--an inflammation of the heart muscle--was nearly four times higher among former COVID-19 patients compared to the control group. There was also an 86% increase in thromboembolic events, such as pulmonary embolisms, among those who had suffered from severe COVID-19.

These findings underline the necessity for ongoing research to understand the prolonged health risks associated with severe COVID-19 infections. The authors of the study advocate for comprehensive and long-term follow-up care for patients who have endured serious COVID-19 conditions.


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